Transcriptional Regulation oa Endothelial Cell And Vascular Development
Identifieur interne : 003037 ( Main/Exploration ); précédent : 003036; suivant : 003038Transcriptional Regulation oa Endothelial Cell And Vascular Development
Auteurs : Changwon Park ; Tae Min Kim ; Asrar B. MalikSource :
- Circulation research [ 0009-7330 ] ; 2013.
Abstract
The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the etiology of vascular diseases. Here we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells towards distinct endothelial cell lineages and its promise in regenerative vascular medicine.
Url:
DOI: 10.1161/CIRCRESAHA.113.301078
PubMed: 23661712
PubMed Central: 3730491
Affiliations:
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